Scratching an itch with VGLUT2
نویسندگان
چکیده
منابع مشابه
On scratching your own itch
Following Massimo Banzi’s comment that the Arduino development board might be seen as a means of ‘scratching your own itch’, this paper explores the concept of affect in relation to physical computing, and investigates the ways in which cybernetic and networked objects could be said to enact a series of process-philosophical and object-oriented tensions. In so doing it addresses the cultural sa...
متن کاملCerebral representation of the relief of itch by scratching.
Cerebral processing of itch-scratching cycles was studied with functional magnetic resonance imaging (fMRI) in healthy volunteers. The back of the hand was repetitively scratched in the absence and presence of itch induced by histamine applied close to the scratched site. Blood-oxygenation-level-dependent (BOLD) effects were assessed in predefined cortical and subcortical brain regions of inter...
متن کاملItch Relief by Mirror Scratching. A Psychophysical Study
OBJECTIVE The goal of this study was to test whether central mechanisms of scratching-induced itch attenuation can be activated by scratching the limb contralateral to the itching limb when the participant is made to visually perceive the non-itching limb as the itching limb by means of mirror images. METHODS Healthy participants were asked to assess the intensity of an experimentally induced...
متن کاملVGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress Itch
Itch can be suppressed by painful stimuli, but the underlying neural basis is unknown. We generated conditional null mice in which vesicular glutamate transporter type 2 (VGLUT2)-dependent synaptic glutamate release from mainly Nav1.8-expressing nociceptors was abolished. These mice showed deficits in pain behaviors, including mechanical pain, heat pain, capsaicin-evoked pain, inflammatory pain...
متن کاملSpinal cord interneurons expressing the gastrin-releasing peptide receptor convey itch through VGLUT2-mediated signaling
Itch is a sensation that promotes the desire to scratch, which can be evoked by mechanical and chemical stimuli. In the spinal cord, neurons expressing the gastrin-releasing peptide receptor (GRPR) have been identified as specific mediators of itch. However, our understanding of the GRPR population in the spinal cord, and thus how these neurons exercise their functions, is limited. For this pur...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2010
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn2970